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Chronic Kidney Failure

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Bone Problems in Chronic Kidney Failure

Bone Problems in Chronic Kidney Failure

Chronic Kidney Failure is a refractory illness which is always accompanied with lots of problems. Bone problem can also a concern. Well, what are the most common problems in chronic kidney failure? And what causes them?

The most common bone problems in chronic kidney failure include osteitis fibrosa cystica, adynamic bone disease, osteomalacia and osteoporosis, which may cause discomforts like bone pain, bone fracture and difficulty in walking. Although bone problem is the not leading cause of death among kidney failure patients, we should attach enough attention, so as to avoid unexpected problems.

In chronic kidney failure, many conditions can contribute the onset of bone problem and they are:

- Metabolic disturbance of calcium and phosphorus

In chronic kidney failure, kidneys can not work normally to remove excess phosphorus, leading to high phosphorus level in blood. When phosphorus level in blood goes up, calcium level in blood decreases, which can cause increase of ( PTH) parathyroid Hormone in the body. PTH works on bone and make our bone to release calcium, so as to increase calcium in blood. When this condition becomes severe, bone problems are caused.

- Metabolic disturbance of vitamin D

In chronic kidney failure, phosphorus level in blood increases, and this severely inhibits the synthesis of 1.25(OH)2D3 which is able to help our body absorb enough calcium. When the content of 1.25(OH)2D3 decreases, plus strict diet limitation, calcium level in blood keeps decreasing, finally leading to bone problem.

- Metabolic acidosis

Chronic kidney failure causes metabolic acidosis easily. Metabolic acidosis not only affects the synthesis of 1.25(OH)2D3, but also impairs the absorption of gastrointestinal tract to calcium, which increases risk for bone problem.

In chronic kidney failure, bone problems are especially common among patients who have severe electrolyte disturbance and tight control of these problems is very helpful for a good life expectancy.

Tag: Kidney Failure Symptoms Kidney Failure Complications

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