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IgA Nephropathy

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Is There Any Permanent Cure for IgA Nephropathy

Is There Any Permanent Cure for IgA NephropathyIgA Nephropathy is an autoimmune disease which relapses easily. Frequent relapse worsens kidney condition and as a consequently, kidney failure is caused. Therefore, instead of getting temporary remission, many patients wonder if there is a any permanent cure for IgA Nephropathy and what can they do to stop frequent relapse.

Is there any permanent cure for IgA Nephropathy?

A cure is the end of a medical condition. For IgA Nephropathy patients, if they get completely recovery and never be bothered by this illness again, we can say they are cured permanently.

IgA Nephropathy is an illness related with immune system and kidney disorder. Immune system protects us from harmful substances, and that is the reason we can live well with lots of bacterium and virus around us. However, in cases of IgA Nephropathy, immune system fails to work well and for this reason, large amounts of IgA (Immunoglobulin A), an antibody that can help us fight against harmful substances, are produced. They combine with each other or with antigen, and as a result of this, IgA immune complexes are produced.

IgA immune complexes deposit in mesangial area easily for some reasons. When they lodge there, inflammation appears. Inflammation is the direct cause of kidney damages in IgA Nephropathy. In early stage, by normalizing immune system and repairing injured kidney tissues, IgA Nephropathy can be cured. However, in advanced stage, some injured kidney intrinsic cells are dead. As dead kidney cells can not be revived, so there is no permanent cure at that time.

What can we do to prevent frequent illness relapse with IgA Nephropathy?

Although there is no permanent cure for patients with IgA Nephropathy in advanced stage, but there is way to stop illness progression and frequent illness relapse:

1. Normalizing immune system

IgA Nephropathy is an autoimmune illness and the appearance of it is due to immune disorder, so normalizing immune system is one of the most important steps in treating IgA Nephropathy.

2. Removing IgA immune complexes away from blood and kidney

IgA immune complexes deposit in kidney, leading to inflammation. Therefore, just by blocking inflammation is far from enough, we also need to clear them away from blood and kidney. Only in this way, can further kidney damages be prevented fundamentally.

3. Repair injured kidney intrinsic cells

In a damaged kidney, there are totally three parts of kidney intrinsic cells: healthy kidney cells, injured kidney intrinsic cells and dead cells. As we have mentioned, dead kidney cells can not be revived, but this does not mean injured kidney can not be repaired. Similar with cells in our hand, kidney cells also have a certain self-curative ability. By this special function, injured kidney cells can be repaired and impaired kidney function can be partly improved.

4. Protect residual kidney tissues

IgA Nephropathy progresses as more and more kidney tissues are injured, so by protecting residual kidney tissues, new kidney damages can be avoided. Consequently, illness progression is stopped.

Lastly, although not everyone with IgA Nephropathy will get permanent cure, but with systematic treatment, it is quite possible for them to live a high quality life.

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