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How Is Proteinuria Formed in Kidney Disease

How Is Proteinuria Formed in Kidney DiseaseProteinuria refers to the presence of excessive protein in urine which is an abnormal condition. In normal condition, no protein can be detected with routine urine test, but in cases of kidney disease, large amounts of protein leak in urine. Why is this? How is proteinuria formed on earth in kidney disease?

Kidney is the organ which is responsible for filtering blood which is composed of blood cells, plasma, platelets and protein and so on. While flowing through kidney with blood, most of these substances are preserved in the body and only a very small amount of them can pass through glomeruli and then get into renal tubule where most of them are reabsorbed back to the blood again. Finally, only less than 150mg of protein get into urine. Under such a condition, lab test shows negative about protein in urine, as the protein in urine is so less.

In cases of kidney disease, protein get into urine mainly due to:

1. Glomeruli are injured

While blood flow through glomeruli, most of the protein are preserved in the body. However, when they are injured, lots of protein will be leaked out. Renal tubule only reabsorbs a certain protein back to the body, so when large amounts of protein get into renal tubule, only some of them are reabsorbed and the rest of them get into urine, leading to proteinuria.

2. Renal tubule is damaged

Renal tubule is in charge of reabsorbing nutrition like protein that filtered by glomeruli. When renal tubule fails to work properly, protein which should be reabsorbed back to the body will get into urine. As a result of this, proteinuria is formed.

3. Both glomerulus and renal tubule are damaged

Proteinuria also can be formed when both glomeruli and renal tubule are injured.

Lastly, protein is a clinical manifestation of kidney disease, but it does not mean all the people with proteinuria have kidney problem, because many other conditions like urinary tract infection and high protein diet also cause present of protein in urine.

Tag: CKD Symptoms Proteinuria

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